Simply put, the Entourage effect is like the difference in beneficial result from eating the whole fresh carrot vs. taking a pill with beta-carotene contained as a chemically isolated supplemental vitamin. Dr Ethan Russo likes to refer to the entourage effect as being similar to the workings of an orchestra playing a symphony THC is a soloist who is supported by balancing harmony supplied by the essential oils (or terpenes), Alpha Pinene and Beta Caryophylene whose presence boosts the performance of THC and hence the "orchestra" or Entourage Effect. The audience experiencing the music is the endocannabinoid system found in all mammals.
The THC Synergy
The isolation of an active ingredient argument, that is so prevalent in novel medicine, is challenged by the idea that THC, the cannabinoid that induces the "high" feeling, has for medical purposes been isolated into a number of remedies since the early 70ies. However none of these therapeutics have any recreational appeal close to that of smoked cannabis. THC is patented in the form of the pharmaceutical drug called Marinol. Marinol has never been abused nor is it on record for ever been stolen! This is because pure THC, without the rest of the orchestra found in a whole plant line up, does not leave one feeling great and causes unpleasant anxiety and unwarranted paranoia. THC requires the presence of the cannabis plant ensemble, to balance its solo effects thus creating the Entourage Effect.
This synergy works visa versa too, as collectively, they enhance their cellular interactions . The cannabinoids and terpenes found in the Cannabis Sativa plant list of natural ingredient - all the subject of much scientific research at present - all have a role to play in creating a wellness effect called homeostasis.
The ingredients behind the effect
The Entourage Effect speaks to the benefit of using the full ingredients list of a natural recipe, not just one isolated ingredient that has been created by a chemist. A truly natural way to achieve maximum wellness benefits. Entourage Oil has a very mild "effect" when taken at the recommended dosage of x 1 drop.
The Entourage Effect was first described in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam, as the basic idea, of the entourage effect is that cannabinoids and terpenes (essential oils) that occur naturally within the cannabis plant, work together creating a heath promoting synergy. Our body is familiar with these processes, which are similar to the functioning of the body’s own Endocannabinoid System.
The entourage effect theory has been described by plant medicine research scientists Wagner and Ulrich-Merzenich (Wagner et al., Phytomedicine, 2009, Vol. 16(2-3), pages 97-110), They define the four basic mechanisms of WHOLE PLANT extracts working to create synergy.
Whole Plant / Entourage effecting extractions have the ability to:
Affect multiple targets / systems within the body
Improve the absorption of all active ingredients into the body
Overcome bacterial defence mechanisms
Minimise adverse side effects
A cancer survivor’s journey with Entourage Oil
78 year old Bruce Smith talks about his Cancer journey that began in 2015 and discusses the benefits of taking Entourage Oil for a wellness effect throughout this challenging period. He had extensive chemotherapy treatment and with incredible tenacity and courage, passed his 7th Dan black belt grading in JKA Karate during this time. He talks about dealing with the intense pain and inflammation experienced with Hodgkin’s Lymphoma Cancer Chemotherapy and the benefits he felt from the low concentration full spectrum cannabis oil called Entourage Oil.
For a more academic presentation see Doctor Ethan Russo's presentation entitled The Endocannabinoid System in Health and Disease. Ethan Russo, MD, is a board-certified neurologist, psychopharmacology researcher, and author. He is the Founder and CEO ofcredo-science.com. Previously, he was Director of Research and Development of theInternational Cannabis and Cannabinoids Institute(ICCI) based in Prague, Czech Republic. Medical Director ofPHYTECS(2015-2017), a biotechnology company researching and developing innovative approaches targeting the human endocannabinoid system, and from 2003-2014, he served as Senior Medical Advisor, medical monitor and study physician toGW Pharmaceuticals, United Kingdom for numerous Phase I-III clinical trials of Sativex® for alleviation of cancer pain unresponsive to optimized opioid treatment and initial studies of Epidiolex® for intractable epilepsy
Dr Russo is a leading light in the effort to bring medical cannabis back into the healing space. Additional information including links to over 81 research papers can be found at Research Gate.
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